Acknowledgements This work has been supported by National Natural Science Foundation of China grants (W2412122, 82470195, 82200208), Natural Science Foundation of Tianjin grants (24JCYBJC00780, 24ZXZSSS00050), State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine grants (QZ 23-6, 23-4), Jin Men Medical Talents of Tianjin (TJSJMYXYC-D2-039), Clinical Oncology Research Fund of CSCO grant (Y-2024AZ(BTK)MS-0040) and Tianjin Key Medical Discipline (Specialty) Construction Project grant (TJYXZDXK-009A)
However, NADPH can also be formed directly in the mitochondria by NAD(P) + transhydrogenase, mitochondrial/cytosolic NADP-dependent isocitrate dehydrogenase, or cytosolic malate dehydrogenase [125]
4.9 Spm reduced MetSO accumulation Met, an amino acid required for the synthesis of Spm, was significantly upregulated under drought stress, possibly because of the blocked conversion of Met to Spm under drought stress
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